Dr. Greenlee is an independent medicinal chemistry consultant and former senior director and vice president of chemistry at Merck Research Labs and Schering-Plough Research Institute, where he specialized in cardiovascular and CNS-related indications. He provided leadership to research groups that advanced 20 drug candidates into preclinical development and 11 into clinical studies, including the marketed drugs Vasotec™, Prinivil™, and Zontivity™. He is co-author of over 240 publications and co-inventor of over 80 U.S. patents. He was elected as a fellow of the American Chemical Society, the American Association for the Advancement of Science, and in 2004 was given the Alfred Burger Award and inducted into the ACS Medicinal Chemistry Hall of Fame. Dr. Greenlee holds a B.S. from the Ohio State University, and a Ph.D. from Harvard University, where he worked with Nobel laureate R. B. Woodward.

Dr. Flaumenhaft is Professor of Medicine at Harvard Medical School and presently Chief of the Division of Hemostasis and Thrombosis at Beth Israel Deaconess Medical Center. His lab discovered that certain antithrombotic small molecules (called parmodulins) act as allosteric ligands of protease-activated receptor 1 (PAR1), and these molecules also have valuable anti-inflammatory properties. His work in platelet biology and thrombotic mechanisms has earned him a Career Award from the Burroughs Wellcome Fund, a Junior Faculty Award from the American Society of Hematology, an Established Investigator Award from the American Heart Association, and an R35 Outstanding Investigator grant from the National Heart, Lung, and Blood Institute. He was also elected to the American Society for Clinical Investigation, and the Association of American Physicians. He received his B.S. from Haverford College and M.D. and Ph.D. degrees from New York University.

Dr. Weiler is a Senior Investigator at the Versiti Blood Research Institute. He is a world expert in coagulation, inflammation biology, sepsis, and hematopoesis, and his lab performed key studies helping to determine the mode of action of activated protein C (aPC) as an anti-inflammatory and anti-sepsis agent. He recently received the International Society on Thrombosis and Haemostasis Esteemed Career Award. Dr. Weiler received B.S., M.S., and Ph.D. degrees from Technische Hochschule Darmstadt.

Dr. Isermann is Professor of Laboratory Medicine and Clinical Chemistry at Leipzig University. He is a world expert in the role of endothelial dysfunction and coagulation protease-dependent signaling in the context of chronic vascular disease and reproductive biology. His lab has determined the relevance of protease-activated receptors to kidney disease and ischemia-reperfusion disease, and in particular determined that parmodulins mimic the anti-inflammatory actions of aPC in mouse models of myocardial infarction and diabetic nephropathy. In 2018 he received the German Bioregion Innovation Prize, and from 2017-19 was President of the German Society of Clinical Pathology and Clinical Chemistry. He holds an M.D. from University Würzburg.

Dr. Lorenzo is Professor of Medicine and Orthopaedics and Director of Bone Biology Research at the University of Connecticut Health Center, where he has performed basic and clinical endocrinology since 1979. He has extensive experience in the treatment of osteoporosis and other metabolic bone diseases, including the characterization of osteoclast formation and function. Recently, his lab determined that PAR1-targeting parmodulins inhibit osteoclast formation and bone resorption in vitro and in vivo. Dr. Lorenzo received his B.S. from Rensselaer Polytechnic Institute and M.D. from the State University of New York, Downstate Medical Center.