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Fighting inflammation-driven disease

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About Us

Function Therapeutics, Inc. is a privately held company aiming to translate recent findings that parmodulins, small molecules that bind to the cell surface receptor PAR1 at an alternative (allosteric) site, promote anti-inflammatory and tissue protective signaling. This novel therapeutic class is under investigation for the treatment of kidney disease and a range of thrombosis and/or inflammation-related disorders. The company was founded based on compounds and assays in the lab of the founder Dr. Chris Dockendorff, complemented by research from collaborators including those at Harvard Medical School, Leipzig University, Versiti Blood Research Institute, and the Medical College of Wisconsin.

Pipetting Samples

Inflammation is a double-edged sword.

Inflammation is the natural cellular response that helps to defend us from infection and rebuild from injury. However, extreme or prolonged levels of inflammation can cause serious damage or mortality. A new class of potential drugs, called parmodulins, can selectively block certain aspects of inflammation while promoting anti-inflammatory signals mediated by protease-activated receptor 1 (PAR1). These "functionally biased" small molecules may represent a novel class of orally active medicines for numerous inflammation-driven disorders. More traditional targets for inflammatory pain are also being matched with molecules rationally designed to lack addictive properties.

49

million

estimated worldwide sepsis cases in 2017

 

25%

estimated severe sepsis mortality rate

0

FDA-approved drugs marketed for sepsis

>25

million

Americans with chronic kidney disease

>5 million

estimated deaths from kidney disease worldwide

0

Current drugs for kidney disease able to reverse renal damage

20

million

estimated Americans with high-impact chronic pain

 

>46,000

U.S. opioid-related overdose deaths in 2018

0

FDA-approved oral opioid analgesics without significant abuse liability